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Sabrina Pollastro PhD

Sabrina Pollastro


Biotechnologist by education, I specialized in bioinformatics and immunology during my PhD done at the AMC under the supervision of Prof. Niek de Vries. In 2019 I joined the group of Prof. Marieke van Ham at Sanquin as PostDoc/Bioinformatician. Given my expertise in B- and T-cell receptor repertoire analysis, my focus within TTB! is to provide the consortium with both practical and bioinformatic help in setting up and performing B-cell receptor clonality analysis. In additon, I am also involved in the analysis of single cell RNA sequencing data and immunomonitoring of of antigen specific T and B cells responses.

Recent publications related to B-cells and antibodies

  1. Pollastro S, Klarenbeek PL, Doorenspleet ME, van Schaik BDC, Esveldt REE, Thurlings RM, Boumans MJH, Gerlag DM, Tak PP, Vos K, Baas F, van Kampen AHC, de Vries N Non-response to rituximab therapy in rheumatoid arthritis is associated with incomplete disruption of the B cell receptor repertoire..  Ann. Rheum. Dis 2019 June
  2. Germar K, Fehres CM, Scherer HU, van Uden N, Pollastro S, Yeremenko N, Hansson M, Kerkman PF, van der Voort EIH, Reed E, Maassen H, Kwakkenbos MJ, Bakker AQ, Klareskog L, Malmström V, de Vries N, Toes REM, Lundberg K, Spits H, Baeten DL. Generation and Characterization of Anti-Citrullinated Protein Antibody-Producing B Cell Clones From Rheumatoid Arthritis Patients. Arthritis Rheumatology 2019 Mar
  3. Chemin K, Pollastro S, James E, Ge C, Albrecht I1, Herrath J, Gerstner C, Tandre K, Sampaio Rizzi T, Rönnblom L, Catrina A, Holmdahl R, Klareskog L, de Vries N, Malmström V. A Novel HLA-DRB1*10:01-Restricted T Cell Epitope From Citrullinated Type II Collagen Relevant to Rheumatoid Arthritis.  Arthritis Rheumatol. 2016 May

Link to full publication list:

Member of work package 2 and 5.

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