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Prof. Joan Hendrik Veelken, MD PhD

Hendrik Veelken

Department of Hematology and LUMC Oncology Center, Leiden University Medical Center.

Precision diagnostics of hematologic malignancies through modern genetic technologies and the role of immunological mechanisms in the origin of malignant lymphomas as the malignancies of the immune system.

5 recent publications related to B-cells and antibodies

  1. M. Dühren-von Minden, R. Übelhart, D. Schneider, T. Wossning, M. Bach, M. Buchner, D. Hofmann, E. Surova, M. Follo, F. Köhler, H. Wardemann, K. Zirlik, H. Veelken, H. Jumaa: Chronic lymphocytic leukemia is driven by antigen-independent, cell autonomous signaling. Nature 489: 309-312, 2012.
  2. Papaioannou, A.M. Strothmeyer, M. Dühren-von Minden, A. Keppler-Hafkemeyer, K. Zirlik, K. Mikesch, C.A. van Bergen, M.A. Navarrete, H. Veelken: Evidence for idiotype-directed immunosurveillance is restricted to follicular lymphoma and attributable to somatic hypermutation. Haematologica 100: e143-146, 2015.
  3. Scherer, M. van der Burgt, S.M. Kiełbasa, C. Bertinetti-Lapatki, M. Dühren-von Minden, K. Mikesch, K. Zirlik, L. de Wreede, H. Veelken, M.A. Navarrete: Selection patterns of B-cell receptors and the natural history of follicular lymphoma. Brit. J. Haematol. 175: 972-975, 2016.
  4. M.T. Koning, E. Quinten, W.H. Zoutman, S.M. Kiełbasa, H. Mei, C.A.M. van Bergen, P. Jansen, R.D. Vergroesen, R. Willemze, M.H. Vermeer, C.P. Tensen, H. Veelken: Acquired N-linked glycosylation motifs in B-cell receptors of primary cutaneous B-cell lymphoma and the normal B-cell repertoire. J Invest. Dermatol. 139: 2195-2203, 2019.
  5. P.C. Maity, M. Bilal, M.T. Koning, M. Young, C.A.M. van Bergen, V. Renna, A. Nicolò, M. Datta, E. Gentner-Göbel, R.S. Barendse, S.F. Somers, R.A.L. de Groen, J.S.P. Vermaat, D. Steinbrecher, C. Schneider, E. Tausch, T. Bittolo, R. Bomben, G. del Poeta, W.G.M. Kroes, J. T. van Wezel, K. Imkeller, C.E. Busse, M. Degano, T. Bakchoul, A.R. Schulz, H. Mei, P. Ghia, K. Kotta, K. Stamatopoulos, H. Wardemann, A. Zucchetto, V. Gattei, S. Stilgenbauer, H. Veelken, H. Jumaa: Immunoglobulin allele IGLV3-21*01 is an inherited risk factor for CLL through the acquisition of a single point mutation enabling autonomous BCR signaling. PNAS 117: 4320-4327, 2020.

Supervised PhD research of

  1. Frank Osterroth, University of Freiburg, 1999
  2. Max Warncke, University of Freiburg, 2007
  3. Maike Buchner, University of Freiburg, 2020

Currently supervision PhD research of

  1. Marvyn T. Koning: BCR repertoire in health and disease
  2. Julieta Sepulveda: Mutational signatures in malignant lymphomas
  3. Ruben de Groen: Precision medicine in malignant lymphoma
  4. Janneke Eken: Autonomous BCR signalling in aggressive B-cell lymphoma

Work package leader WP7 and member of WP 2 and 5.

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