Department of Pediatric Immunology, Rheumatology and Infectious diseases, Emma Children’s Hospital, Amsterdam UMC, Meibergdreef 9, Amsterdam, The Netherlands
Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, Meibergdreef 9, Amsterdam, The Netherlands
The goal of my PhD project is to use this multidimensional approach to verify the role of signalling proteins and receptors of interest in B-cell-into-plasma-cell differentiation and translate this into clinically relevant therapeutic targets for patients with B cell mediated diseases. To study this, we investigate the cellular phenotype and function of lymphocytes in primary immunodeficiencies (PID), as human knock out models and through this delineate normal B cell function and differentiation in health and disease.
Verhoeven D., Stoppelenburg A.J., Meyer-Wentrup F., Boes M. (2018). Increased risk of hematologic malignancies in primary immunodeficiency disorders: opportunities for immunotherapy. Clinical Immunology, 190, 22-31.
Member of workpackage 2 and 5.