Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen.
The goal of my PhD- project is to characterize the circulating autoreactive B cells of granulomatosis with polyangiitis (GPA) patients. A method will be developed to specifically detect, isolate, and characterize these low-frequency cells. For the characterization of the autoreactive B cells, we will study the phenotype and signaling pathways. Overall, we hope to identify novel therapeutic targets for the treatment of GPA patients and relapse risk markers.
Member of work package 2 and 5.