Odilia B. J. Corneth PhD

Odilia Corneth

Pulmonary Medicine, Erasmus MC Rotterdam

My group studies B cells in autoimmune and interstitial lung diseases (ILD). We focus on B cell signaling, which we measure using phosphoflow, a technique we optimised for B cells. We have found that signaling through the B cell receptor (BCR) is increased in patients with active autoimmune disease, and that particularly transitional and naïve B cells are more responsive to stimulation. In parallel, a similar phenotype was found in patients with idiopathic pulmonary fibrosis (IPF), suggesting an underlying immune deregulation. We are currently investigating how signaling deregulation in patients associated with severity of disease and clinical outcome.

Recent publications related to B-cells and antibodies

  1. Aberrant B Cell Receptor Signaling in Naïve B Cells from Patients with Idiopathic Pulmonary Fibrosis. Stefan F H Neys, Peter Heukels, Jennifer A C van Hulst, Jasper Rip, Marlies S Wijsenbeek, Rudi W Hendriks, Odilia B J Corneth Cells 2021 doi: 10.3390/cells10061321
  2. Phosphoflow Protocol for Signaling Studies in Human and Murine B Cell Subpopulations. Jasper Rip, Marjolein de Bruijn, Allard Kaptein, Rudi Hendriks, Odilia Corneth. J Immunol 2020 doi: 10.4049/jimmunol.1901117
  3. Evidence for Enhanced Bruton’s Tyrosine Kinase Activity in Transitional and naïve B Cells of Patients With Granulomatosis With Polyangiitis. Anouk von Borstel, Wayel Abdulahad, Jan Stephan Sanders, Jasper Rip, Stefan Neys, Rudi Hendriks, Coen Stegeman, Peter Heeringa, Abraham Rutgers, Odilia Corneth. Rheumatology 2019 doi: 10.1093/rheumatology/kez205
  4. Enhanced Bruton’s Tyrosine Kinase Activity in Peripheral Blood B Lymphocytes From Patients With Autoimmune Disease. Odilia Corneth, Gwenny Verstappen, Sandra Paulissen, Marjolein de Bruijn, Jasper Rip, Melanie Lukkes, Jan Piet van Hamburg, Erik Lubberts, Hendrika Bootsma, Frans Kroese, Rudi Hendriks. Arthritis Rheumatol. 2017 doi: 10.1002/art.40059
  5. Distinct and Overlapping Functions of TEC Kinase and BTK in B Cell Receptor Signaling. Marjolein de Bruijn, Jasper Rip, Esmee van der Ploeg, Lars van Greuningen, Van Ta, Laurens Kil, Anton Langerak, Guus Rimmelzwaan, Wilfried Ellmeier, Rudi Hendriks, Odilia Corneth. J Immunol. 2017 doi: 10.4049/jimmunol.1601285

PhD research supervision

Jasper Rip (2016 – 2020)

Stefan Neys (2018 – 2022)

Member of WP: Work package leader WP7

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