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Mirjam van der Burg PhD

Mirjam van der Burg

Dept. of Pediatrics, Laboratory for Pediatric Immunology, Leiden University Medical Center

The professional interest of the lab of Mirjam van der Burg is inborn Primary Immunodeficiencies (PID) of the adaptive immune system, especially antibody deficiencies,  severe combined immunodeficiency (SCID) and DNA repair disorders. The research lines are directly related to these entities and aim for early diagnosis via newborn screening, studying the effect of the monogenetic defects on the immune system especially on B and T-cell differentiation and antigen receptor repertoire formation and immune reconstitution after hematopoietic stem cell transplantation.

5 recent publications related to B-cells and antibodies

  1. Delineating Human B Cell Precursor Development With Genetically Identified PID Cases as a Model. Wentink MWJ, T. K, Perez-Andres M, Del Pino Molina L, IJspeert H, Kavelaars F, Lankester AC, Lecrevisse Q, van Dongen JJM, Orfao A, van der Burg M Front Immunol. 2019 Nov 26;10:2680.
  2.  Repertoire Sequencing of B Cells Elucidates the Role of UNG and Mismatch Repair Proteins in Somatic Hypermutation in Humans. IJspeert H, van Schouwenburg PA, Pico-Knijnenburg I, Loeffen J, Brugieres L, Driessen GJ, Blattmann C, Suerink M, Januszkiewicz-Lewandowska D, Azizi AA, Seidel MG, Jacobs H, van der Burg M. Front Immunol. 2019;10:1913.
  3. Identification of CVID Patients With Defects in Immune Repertoire Formation or Specification. van Schouwenburg PA, Ijspeert H, Pico-Knijnenburg I, Dalm VASH, van Hagen PM, van Zessen D, Stubbs AP, Patel SY, van der Burg M. Front Immunol. 2018 Nov 23;9:2545.
  4. User-Friendly, Web-Based Tool for Analysis and Visualization of T and B Cell Receptor Repertoire Data. IJspeert H, van Schouwenburg PA, van Zessen D, Pico-Knijnenburg I, Stubbs AP, van der Burg M. Antigen Receptor Galaxy: A J Immunol. 2017;198:4156-4165.
  5. XLF deficiency results in reduced N-nucleotide addition during V(D)J recombination. IJspeert H, Rozmus J, Schwarz K, Warren RL, van Zessen D, Holt RA, Pico-Knijnenburg I, Simons E, Jerchel I, Wawer A, Lorenz M, Patıroğlu T, Akar HH, Leite R, Verkaik NS, Stubbs AP, van Gent DC, van Dongen JJM, van der Burg M. Blood. 2016 Aug 4;128(5):650-9. https://doi: 10.1182/blood-2016-02-701029

Full publication list:

Currently supervision PhD research of

  1. Fabian Kaiser: Monogenic defects in Primary Immunodeficiencies
  2. Maartje Blom: Neonatal screening for Severe combined immunodeficiency
  3. Michiel Schoenaker: Clinical and diagnostic dilemmas in Ataxia Telangiectasia and Bloom’s syndrome

Supervision of PhD awarded candidates (research related to B-cells and antibodies)

  1. Marjolein Wentink: Connecting B cell differentiation Pathways and antibody deficiencies. Awarded: 2018
  2. Hanna IJspeert: Clinical and Immunological Diversity of Recombination Defects. Awarded: 2014
  3. Gertjan J.A. Driessen: Immunobiology of Primary Antibody Deficiencies: Towards a new classification. Awarded: 2013
  4. Menno C. van Zelm: B-cell development and Primary Antibody Deficiencies. Awarded: 2007

Member of work package 2 and 5.

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