Department of Hematology, Leiden University Medical Center.
I divide my time between fundamental research in the Department of Hematology in the LUMC and working as a clinical resident of Internal Medicine (AIOS) at the Groene Hart Hospital. My research interests are the role of the B-cell receptor in lymphoma, including BCR glycosylation, and the sequencing and analysis of large BCR repertoires in health and non-malignant disease. In the past, we have set up several methods for unbiased BCR sequencing and developed code for in silico rearrangement of BCR repertoires and arrangement and visualisation of subclonal BCR mutations.
5 recent publications related to B-cells and antibodies
- ARTISAN PCR: rapid identification of full-length immunoglobulin rearrangements without primer binding bias. Koning MT, Kiełbasa SM, Boersma V, et al. Br J Haematol. 2017
- Acquired N-Linked Glycosylation Motifs in B-Cell Receptors of Primary Cutaneous B-Cell Lymphoma and the Normal B-Cell Repertoire. Koning MT, Quinten E, Zoutman WH, et al. J Invest Dermatol. 2019
- Peripheral IgE Repertoires of Healthy Donors Carry Moderate Mutation Loads and Do Not Overlap With Other Isotypes. Koning MT, Trollmann IJM, van Bergen CAM, et al. Front Immunol. 2019
- Templated insertions at VD and DJ junctions create unique B-cell receptors in the healthy B-cell repertoire. Koning MT, Vletter EM, Rademaker R, et al. Eur J Immunol. 2020
- IGLV3-21*01 is an inherited risk factor for CLL through the acquisition of a single-point mutation enabling autonomous BCR signaling. Maity PC, Bilal M, Koning MT, et al. Proc Natl Acad Sci U S A. 2020
Full publication list: https://www.researchgate.net/profile/Marvyn_Koning/research
Member of work packages 2 and 5.