Maaike Braham PhD

Maaike Braham

Department Immune Mechanisms (IMM), Centre for Immunology of Infectious diseases and Vaccines (IIV), National Institute for Public Health and the Environment (RIVM).

With a PhD in regenerative medicine, my passion is the development of 3D in vitro models that aid the better mimicking, understanding and/or unraveling of complex cellular interactions within the human body. I previously worked on the development of a 3D in vitro bone marrow model to study primary multiple myeloma cells or hematopoietic progenitor cells.

Within the Target to B! consortium, I am working on the development of a 3D in vitro lymphoid model. The 3D culture of healthy, malignant or autoreactive  B cells in vitro, taking interactions with the surrounding microenvironment into account, will provide the opportunity to study the germinal center reaction, as well as the effect of treatments, in a better representative in vitro system.

5 recent publications related to B-cells and antibodies

  1. Braham, M. V. J., Minnema, M. C., Aarts, T., Sebestyen, Z., Straetemans, T., Vyborova, A., Kuball, J., Öner, F. C., Robin, C., Alblas, J. Cellular immunotherapy on primary multiple myeloma expanded in a 3D bone marrow niche model. Oncoimmunology, 2018. 7(6): p. e1434465.
  2. Braham, M. V. J., Ahlfeld, T., Akkineni, A. R., Minnema, M. C., Dhert, W. J. A., Öner, F. C., Robin, C., Lode, A., Gelinsky, M., Alblas, J., Endosteal and Perivascular Subniches in a 3D Bone Marrow Model for Multiple Myeloma. Tissue Eng Part C Methods, 2018. 24(5): p. 300-312.
  3. Braham, M. V. J., Deshantri, A. K., Minnema, M. C., Öner, F. C., Schiffelers, R. M., Fens, M. H., & Alblas, J., Liposomal drug delivery in an in vitro 3D bone marrow model for multiple myeloma. Int J Nanomedicine, 2018. 13: p. 8105-8118.
  4. Braham, M. V. J., Alblas, J., Dhert, W. J. A., Öner, F. C., & Minnema, M. C., Possibilities and limitations of an in vitro three-dimensional bone marrow model for the prediction of clinical responses in patients with relapsed multiple myeloma. Haematologica, 2019. 104(11): p. e523-e526.
  5. Braham, M. V. J., Li Yim, A. S. P., Garcia Mateos, J., Minnema, M. C., Dhert, W. J. A., Öner, F. C., Robin, C., Alblas, J., A Human Hematopoietic Niche Model Supporting Hematopoietic Stem and Progenitor Cells In Vitro. Adv Healthc Mater, 2019. 8(10): p. e1801444.

Member of work packages 2 and 5.

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