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Linda van der Weele MD

Linda van der Weele

Amsterdam UMC location AMC.
MD PhD student within the group of Niek de Vries and Taco Kuijpers.

My project will focus on BCR-sequencing of different auto-immune mediated disease cohorts; pre- and post-treatment. Our hypothesis is that BCR-repertoire in vivo can predict the outcome of in-vivo inhibition. In the AMC we have already an UMI-based pipeline running. We can sequence on low cell numbers and with the help of robotized assays our results are highly reproducible.

Furthermore I’m working on a new biomarker for disease activity in different disease cohorts. The IgG4:IgG mRNA ratio (qPCR test) reflect disease activity in IgG4-related disease and in ANCA+ vasculitis. Our aims within the Target-to-B! is to determine whether this test can be used as disease activity marker in different types of vasculitis (e.g. GCA) and other cohorts (e.g. pemphigus, myasthenia gravis).

Member of work package 5.

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