Laurent M. Paardekooper
Department of Human Genetics; Leiden University Medical Center.
I am a postdoc in the group of Maartje Huijbers at the Human Genetics department of the LUMC. We focus on the IgG4-mediated autoimmune disease MuSK myasthenia gravis and my goal is to figure out what makes IgG4 B cells stand out from the others and why these cells react to MuSK in the first place. To this end, I want to employ single cell RNA sequencing of B cells in an isotype- and antigen-specific manner to gain insight in their transcriptome. This will help us understand how these cells come to be and how we can target them therapeutically.
Link to full publication list: https://orcid.org/0000-0001-7079-2697
Member of workpackage 5.