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Anne-Marie Buisman PhD

Anne Marie Buisman

Center of Infectious Diseases Control, National Institute of Public Health and the Environment.

After my PhD at the Department of Infectious Diseases of the University of Leiden I started as an immunologist in further research on infectious diseases at the National Institute for Public Health and the Environment (RIVM). Since 2005 I focused on memory B and T-cell responses to vaccine preventable diseases in vaccinated children. Afterwards several clinical studies on vaccine responses in both the young and elderly population have been performed. Since 2012 I am supervising projects on  ‘ageing and immunity’. Nowadays my studies are focussing on frailty, co-morbidities, the susceptibility for infectious diseases and vaccine responsiveness in the ageing population.

5 recent publications related to B-cells and antibodies

  1. Samson LD*, van den Berg SP*, Engelfriet P, Boots AM, Hendriks M, de Rond LG, de Zeeuw-Brouwer ML, Verschuren WM, Borghans JA, Buisman AM#, van Baarle D#. Limited effect of duration of CMV infection on adaptive immunity and frailty: insights from a 27-year-long longitudinal study.  Clin Transl Immunology. 2020 Oct 14;9(10):e1193. doi: 10.1002/cti2.1193. Both first* and last# authors equally participated.
  2. Samson LD, H Boots AM, Ferreira JA, J Picavet HS, de Rond LGH, de Zeeuw-Brouwer ML, Monique Verschuren WM, Buisman AM, Engelfriet P. In-depth immune cellular profiling reveals sex-specific associations with frailty. Immun Ageing.2020 23;17:20. doi: 10.1186/s12979-020-00191-z.
  3. Van der Lee S, Sanders EAM, Berbers GAM, Buisman AM. Whole-cell or acellular pertussis vaccination in infancy determines IgG subclass profiles to DTaP booster vaccination. Vaccine. 2018 Jan 4;36(2):220-226. doi: 10.1016/j.vaccine.2017.11.066. Epub 2017 Dec 1.
  4. Van der Heiden M, van Ravenhorst MB, Bogaard M, Boots AM, Berbers GAM, Buisman AM. Lower antibody functionality in middle-aged adults compared to adolescents after primary meningococcal vaccination: Role of IgM. Exp Gerontol. 2017 Dec 26. pii: S0531-5565(17)30654-X. doi:
  5. Doedée AM, Kannegieter N, Öztürk K, van Loveren H, Janssen R, Buisman AM. Higher numbers of memory B-cells and Th2-cytokine skewing in high responders to hepatitis B vaccination. Vaccine. 2016 Apr 27;34(19):2281-9.

Currently supervising 4 PhD- students.

Supervision of PhD awarded researchers

  1. Hendrikx LH (dec 2011, UU) Pertussis vaccinations in Dutch children, memory immune responses.
  2. Van der Heiden M (jan 2018, UG), Strengthening memory immunity in the ageing population.
  3. Van der Lee S (april 2018, UU), Persistence of Pertussis immunity in children and adults

Member of work package 2 and 5.

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